Marginal means/rates models for multiple type recurrent event data.
نویسندگان
چکیده
Recurrent events are frequently observed in biomedical studies, and often more than one type of event is of interest. Follow-up time may be censored due to loss to follow-up or administrative censoring. We propose a class of semi-parametric marginal means/rates models, with a general relative risk form, for assessing the effect of covariates on the censored event processes of interest. We formulate estimating equations for the model parameters, and examine asymptotic properties of the parameter estimators. Finite sample properties of the regression coefficients are examined through simulations. The proposed methods are applied to a retrospective cohort study of risk factors for preschool asthma.
منابع مشابه
Modelling recurrent events: a tutorial for analysis in epidemiology.
In many biomedical studies, the event of interest can occur more than once in a participant. These events are termed recurrent events. However, the majority of analyses focus only on time to the first event, ignoring the subsequent events. Several statistical models have been proposed for analysing multiple events. In this paper we explore and illustrate several modelling techniques for analysi...
متن کاملMarginal regression models with time-varying coefficients for recurrent event data.
Recurrent event data arise frequently from medical research. Examples include repeated infections, recurrence of tumors, relapse of leukemia, repeated hospitalizations, recurrence of symptoms of a disease, and so on. In the analysis of recurrent event data, the proportional rates model assumes that the regression coefficients are time invariant. In reality, however, these parameters may vary ov...
متن کاملSome Issues in Marginal Recurrent Event Cox type Models
Recurrent event analysis has been a topic that has generated much attention in the last few years. The analysis of recurrent event data can be a complex task, with many different relationships and dependencies that need to be specified. One aspect of recurrent events that is difficult to specify, and even more complex to justify, is the relationship a subject’s rate of failure will have as even...
متن کاملAspects of the analysis of multivariate failure time data
Multivariate failure time data arise in various forms including recurrent event data when individuals are followed to observe the sequence of occurrences of a certain type of event; correlated failure time when an individual is followed for the occurrence of two or more types of events for which the individual is simultaneously at risk, or when distinct individuals have dependent event times; o...
متن کاملFlexible estimation of differences in treatment-specific recurrent event means in the presence of a terminating event.
In this article, we consider the setting where the event of interest can occur repeatedly for the same subject (i.e., a recurrent event; e.g., hospitalization) and may be stopped permanently by a terminating event (e.g., death). Among the different ways to model recurrent/terminal event data, the marginal mean (i.e., averaging over the survival distribution) is of primary interest from a public...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Lifetime data analysis
دوره 10 2 شماره
صفحات -
تاریخ انتشار 2004